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KMID : 0882419930450060788
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Korean Journal of Medicine
1993 Volume.45 No. 6 p.788 ~ p.794
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Pattern of Immune Deposits in Articular Cartilage
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유대현
정성수/이인홍/배상철/김성윤/김신규/정현기/최일용
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Abstract
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ground : Immune deposits were found on the articular surface of rheumatoid arthritis and osteoarthritis even though the prevalence and pattern of immune deposits were different between rheumatoid arthritis and osteoarthritis. Authors conducted
this
study to compare the pattern and positive rate of immune deposits on surface of articular cartilage between rheumatoid arhtritis and osteorthritis.
Methods : Articular cartilages were obtained from patients who were conducted total joint
replacement surgery at knee or hip joint. Selected cases were 15 cases of rheumatoid arthritis,
45 cases of osteoarthritis. Immune deposits were searched using direct immunofluorescent
technique with FITC conjugated anti-IgG, IgA, IgM, C3 antibody.
Results :
1) Positive rate of immune deposits on articular cartilage was 66.7% in rheumatoid arthrtis
and 26.7% in osteoarthritis.
2) Granular staining pattern was found in only 6 patients out of 10 posotive patients with
rheumatoid arthritis. In osteoarthritis, the pattern of immune deposits was not granular but
nongranular pattern such as intermittent linear or linear pattern.
3) Positive rate in primary osteoarthrits and secondary arthritis was 32% and 26.7%
respectively.
4) Rheumatoid factor was reactive not only in 6 cases with granular pattern but also in 3
cases without immune deposits and in 2 cases with nongranular pattern.
Conclusion : Immune deposits was found more frequently in rheumatoid arthritis than
osteoarthritis and granular pattern was noted in cases with rheumatoid arthritis only. The
differences in prevalence and pattern of immune deposits between rheumatoid arthritis and
osteoarthritis may be due to different antigen, mechanism of imune deposition or anther
unknown factors. Further investigation have to be conducted in these respects.
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